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Subsite specificity of divalent metal ions to glucosyltransferase
1Department of Basic Sciences, University of Southern California, Los Angeles 90089-0641, USA.
Journal of Craniofacial Genetics and Developmental Biology
|December 2, 2000
Abstract:
Glucosyltransferase from oral bacteria Streptococcus mutans is the most significant virulent factor in causing dental caries. The enzyme has two subsites. The binding specificity of divalent metal ions to glucosyl or fructosyl subsite was examined using multiple inhibition kinetics. The interaction factor "alpha" identifies whether the two subsites are exclusive or non-exclusive.