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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Non-hematopoietic cutaneous metastases in children and adolescents: thirty years experience at St. Jude Children's

W A Wesche¹, V K Khare, T M Chesney

¹Department of Pathology, The University of Tennessee, Memphis, USA.

Journal of Cutaneous Pathology

|December 2, 2000

Summary

Pediatric non-hematopoietic malignancies rarely spread to the skin, often presenting as the initial sign of disease. Rhabdomyosarcoma and neuroblastoma are the most common culprits in children.

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Area of Science:

Pediatric Oncology
Dermatopathology
Cancer Metastasis

Background:

The spectrum of cutaneous metastasis from non-hematopoietic neoplasms in pediatric patients is not well-documented.
This study examines the histologic diversity of this rare process over three decades at a specialized pediatric cancer center.

Purpose of the Study:

To document the histologic types of non-hematopoietic malignancies that metastasize to the skin in children.
To identify the primary pediatric tumors most frequently associated with cutaneous metastasis.

Main Methods:

A retrospective review of pathology accessions from skin biopsies and autopsies was conducted.
Cases coded for metastatic non-hematopoietic malignancy were identified and analyzed.

Main Results:

Out of 1,971 skin-related pathology accessions, 40 cases (2%) showed metastatic non-hematopoietic malignancy.
The most frequent diagnoses included neuroblastoma (8 cases) and various types of rhabdomyosarcoma (14 cases).
Other diagnoses included osteosarcoma, choriocarcinoma, Ewing's sarcoma, and malignant melanoma.

Conclusions:

Cutaneous metastasis of non-hematopoietic malignancies in children is uncommon but can be the initial presentation.
Rhabdomyosarcoma and neuroblastoma are the primary pediatric tumors most likely to metastasize to the skin.
Pediatric tumors are more prone to widespread dissemination to multiple distant sites compared to adult malignancies.