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Related Experiment Videos

Crosslinkable coatings from phosphorylcholine-based polymers.

A L Lewis1, Z L Cumming, H H Goreish

  • 1Research and Development Group, Biocompatibles Ltd, Farnham, Surrey, UK. andrew_lewis@biocompatibles.co.uk

Biomaterials
|December 2, 2000
PubMed
Summary
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This study synthesized biocompatible polymer coatings using 2-methacryloyloxyethyl phosphorylcholine (MPC) and other monomers. These advanced coatings effectively reduce bacterial adhesion and enhance the biocompatibility of medical devices.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • Biocompatible coatings are crucial for medical devices to minimize adverse biological responses.
  • Developing advanced polymer materials with controlled crosslinking is essential for tailored surface properties.

Purpose of the Study:

  • To synthesize and characterize novel crosslinked polymer membranes using 2-methacryloyloxyethyl phosphorylcholine (MPC).
  • To evaluate the physical and biological properties of these polymers for medical device applications.
  • To establish a basis for post-crosslinkable polymers with improved biocompatibility and reduced bacterial adhesion.

Main Methods:

  • Free radical copolymerization of MPC, lauryl methacrylate, hydroxypropyl methacrylate, and trimethoxysilylpropyl methacrylate.

Related Experiment Videos

  • Characterization using NMR, FT-IR, viscometry, and elemental analysis.
  • Evaluation of crosslink density and curing via AFM, nanoindentation, protein adsorption assays, blood contacting experiments, and enzyme immunoassay for E. coli detection.

    • Main Results:

    • Optimal crosslink density achieved with 5 mol% silyl crosslinking agent.
    • Crosslinking enhanced coating elasticity.
    • Demonstrated significant reduction in protein adsorption and bacterial adhesion (E. coli).
    • Coatings exhibited improved biocompatibility in blood contacting experiments.

    Conclusions:

    • The synthesized MPC-based polymers are highly effective as coatings for medical devices.
    • These coatings significantly enhance biocompatibility and reduce bacterial colonization.
    • The materials show promise for improving the safety and efficacy of various medical implants and devices.