Related Experiment Videos
A remarkably simple chemicoenzymatic approach to structurally complex bicyclo[3.1.0]hexane carbocyclic nucleosides
H R Moon1, H Ford, V E Marquez
1Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, FCRDC, Frederick, Maryland 21702-1201, USA.
Organic Letters
|December 2, 2000
Abstract:
[reaction: see text] Intramolecular cyclopropanation of a carbene engendered from the corresponding diazo beta-ketoester produced the desired bicyclo[3.1. 0]hexane pseudosugar. Purine nucleosides obtained via Mitsunobu coupling were resolved with adenosine deaminase. The requisite beta-ketoester was assembled in one step from ethyl acetoacetate and acrolein.