Related Experiment Video
Updated: Jul 26, 2026

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
Published on: March 27, 2019
Association of bronchopulmonary sequestration with expression of the homeobox protein Hoxb-5
M V Volpe1, K Archavachotikul, I Bhan
1Division of Newborn Medicine, Department of Pediatrics, Department of Pathology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract:
Bronchopulmonary sequestration (BPS) is caused by the abnormal development of an accessory lung diverticulum from the foregut very early in embryogenesis. The developmental abnormalities seen with BPS suggest that this anomaly is caused by abnormal expression of homeobox genes, which control axial identity and organ-specific patterning during embryogenesis. The authors previously have shown that the homeobox gene Hoxb-5 is necessary for normal airway branching during lung development. The authors now report that BPS is associated with aberrant developmental expression of Hoxb-5 protein, suggesting that this Hox gene is involved in the development of BPS.
Related Concept Videos
Pleiotropy
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Hedgehog Signaling Pathway
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

