Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Projection neurons with shared cotransmitters elicit different motor patterns from the same neural circuit.

D E Wood1, W Stein, M P Nusbaum

  • 1Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6074, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 11, 2000
PubMed
Summary

Different neurons use the same neurotransmitters in unique ways to control neural circuits. The neuropeptide CabTRP Ia in one neuron partially explains its distinct control over rhythmic activity in the crab stomatogastric nervous system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscular expression of <i>pezo-1</i> differentially contributes to swimming and crawling production in the nematode <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2024
Same author

Drug monitoring detects under- and overdosing in patients receiving 5-fluorouracil-containing chemotherapy-results of a prospective, multicenter German observational study.

ESMO open·2023
Same author

Gastrointestinal Tract Reconstruction in Adults with Ultra-Short Bowel Syndrome: Surgical and Nutritional Outcomes.

Surgery·2020
Same author

Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy.

Proceedings of the National Academy of Sciences of the United States of America·2019
Same author

Cyclic Nucleotide-Mediated Modulation of the Pyloric Motor Pattern in the Stomatogastric Ganglion of the Crab Cancer borealis.

The Biological bulletin·2018
Same author

[Effect of pneumoencephalography on clumping of leukocytes].

Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina·2014

Area of Science:

  • Neuroscience
  • Neurophysiology
  • Computational Neuroscience

Background:

  • Neuronal specificity is often linked to unique cotransmitter combinations.
  • The stomatogastric nervous system (STG) in Cancer borealis provides a model for studying neural circuit modulation.
  • Projection neurons like modulatory proctolin neuron (MPN) and modulatory commissural neuron 1 (MCN1) influence STG rhythms.

Purpose of the Study:

  • To investigate the role of Cancer borealis tachykinin-related peptide Ia (CabTRP Ia) in differentiating the functions of MCN1 and MPN.
  • To test the hypothesis that distinct cotransmitter complements confer neuronal specificity.

Main Methods:

  • Selective activation of projection neurons MPN and MCN1 in the crab STG.
  • Pharmacological blockade of tachykinin receptors using Spantide I to assess the contribution of CabTRP Ia.

Related Experiment Videos

  • Analysis of resulting rhythmic outputs (gastric mill and pyloric rhythms).

    • Main Results:

    • MCN1 activation elicits both gastric mill and pyloric rhythms, while MPN elicits only a pyloric rhythm.
    • Blocking CabTRP Ia action with Spantide I abolished the gastric mill rhythm elicited by MCN1.
    • The pyloric rhythm elicited by MCN1, even without CabTRP Ia, remained distinct from the MPN-elicited pyloric rhythm.

    Conclusions:

    • CabTRP Ia partially accounts for the distinct neural outputs of MCN1 and MPN.
    • Projection neurons may employ diverse strategies, including differential use of cotransmitters, to generate distinct network outputs.
    • This supports the hypothesis that neuronal specificity arises from a combination of factors, not solely distinct cotransmitter sets.