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T cell differentiation: a mechanistic view
1Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. avni@cbr.harvard.edu
Current Opinion in Immunology
|December 5, 2000
Abstract:
It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.