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Vancomycin-Resistant Enterococcus faecium: First Case in Brazil.

Dalla Costa LM¹, Souza, Martins

¹Laboratory of Bacteriology and Pediatric Department,Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases

|December 5, 2000

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A fatal case of septicemia caused by vancomycin-resistant Enterococcus faecium (VRE) occurred in a 9-year-old girl with aplastic anemia. This marks the first reported VRE clinical case in Brazil, highlighting a significant public health concern.

Area of Science:

Infectious Diseases
Hematology
Clinical Microbiology

Background:

Aplastic anemia poses significant risks for opportunistic infections.
Enterococcus faecium is a known cause of hospital-acquired infections.
Antimicrobial resistance, particularly to vancomycin, is a growing global health threat.

Purpose of the Study:

To report a rare fatal case of VRE septicemia in a pediatric patient.
To document the antimicrobial resistance profile of the VRE isolate.
To highlight the emergence of VRE in Brazil.

Main Methods:

Case report of a 9-year-old girl with aplastic anemia.
Identification and antimicrobial susceptibility testing of the causative agent.
Clinical data review and outcome assessment.

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Main Results:

The patient developed fatal septicemia due to vancomycin-resistant Enterococcus faecium.
The VRE isolate exhibited resistance to ampicillin, teicoplanin, high-level gentamicin, and high-level streptomycin.
This represents the first reported VRE case from a clinical specimen in Brazil.

Conclusions:

Vancomycin-resistant Enterococcus faecium poses a critical threat in immunocompromised patients.
The emergence of VRE in Brazil necessitates enhanced surveillance and infection control measures.
Multidrug-resistant organisms require careful monitoring in clinical settings.