Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bones of the Lower Limb: Tibia and Fibula01:10

Bones of the Lower Limb: Tibia and Fibula

The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population.

Journal of endocrinological investigation·2024
Same author

Apparent autistic traits in transgender people: a prospective study of the impact of gender-affirming hormonal treatment.

Journal of endocrinological investigation·2022
Same author

MPFL reconstruction and tibial tuberosity transposition in patients with patellar instability: May it troubleshots also trochlear dysplasia?

Journal of experimental orthopaedics·2021
Same author

SIGIS-SIAMS-SIE position statement of gender affirming hormonal treatment in transgender and non-binary people.

Journal of endocrinological investigation·2021
Same author

The role of six biomarkers in diagnosis of hemophilic arthropathy: review of the literature.

Journal of biological regulators and homeostatic agents·2020
Same author

Knee arthroplasty system with medialized keel: Seven-year follow-up of a pioneer cohort.

The Knee·2020

Related Experiment Video

Updated: Jul 14, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

[Fibrocartilaginous dysplasia and tibia vara in young children: presentation of 3 new cases with spontaneous

D Ceroni1, M Mosconi, A DiMeglio

  • 1Unité d'Orthopédie et de Traumatologie Infantile, Hôpital des Enfants, Genève, Suisse.

Acta Orthopaedica Belgica
|December 5, 2000
PubMed
Summary

Focal fibrocartilaginous dysplasia in toddlers is a benign condition linked to tibia vara. This condition often resolves spontaneously, suggesting that biopsies and surgery are unnecessary.

More Related Videos

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Related Experiment Videos

Last Updated: Jul 14, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Area of Science:

  • Orthopedics
  • Pediatric Radiology
  • Developmental Biology

Background:

  • Focal fibrocartilaginous dysplasia (FFD) is a rare, benign condition.
  • It is frequently associated with unilateral tibia vara in toddlers.
  • Understanding its natural history is crucial for appropriate management.

Observation:

  • Three new cases of FFD in children aged 17, 18, and 26 months are presented.
  • All reported cases demonstrated spontaneous resolution of the condition.
  • This observation supports a self-limiting nature of FFD.

Findings:

  • A meta-analysis was conducted to review the natural history of FFD.
  • Diagnostic and pathophysiological challenges associated with FFD were examined.
  • Spontaneous remodeling of varus angulation and bony defects is a key finding.

Implications:

  • Biopsy and surgical interventions for FFD are generally not recommended.
  • Conservative management is favored due to the potential for spontaneous healing.
  • This study guides clinical decision-making for pediatric bone conditions.