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Updated: Jul 11, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 9, 2011
Stochastic models for systems of interacting ion channels
1School of Mathematical Sciences, University of Nottingham, UK. fgb@maths.nott.ac.uk
Abstract:
We consider a variety of Markov based models for systems of ion channels exhibiting dependence between channels. It is shown how many useful properties which may be calculated for an aggregated single-channel model, or a system of independent channels, can be extended to various types of interacting channel systems. Key structure and results from the theory of aggregated Markov processes are summarized in a convenient matrix form. These are then applied to the superposition of independent and dependent channels, including a patch of channels in a random environment, and a system of channels with spatial interactions. Calculations based on the resultant matrix expressions and intensity arguments can be implemented straightforwardly in a matrix-oriented package such as Matlab. The role of reversibility is also studied. A number of examples illustrate the strengths of the methods and enable numerical comparisons between the different types of systems.
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