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Related Experiment Videos

Semaphorin function in the developing invertebrate peripheral nervous system.

J Bonner1, T P O'Connor

  • 1Department of Anatomy, University of British Columbia, Vancouver, Canada.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|December 5, 2000
PubMed
Summary
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Semaphorins guide developing neurons. Two specific semaphorins in grasshopper limb buds work together, establishing sensory projections through a hierarchical guidance system.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Semaphorin family proteins are crucial secreted and transmembrane molecules involved in guiding neuronal development.
  • Distinct expression patterns of semaphorins are observed within the developing grasshopper limb bud.

Purpose of the Study:

  • To review the function of two specific semaphorins in axonal guidance during neuronal development.
  • To propose a model for a hierarchical guidance system in the developing peripheral nervous system.

Main Methods:

  • Review of existing literature on semaphorin function in axonal guidance.
  • Analysis of distinct semaphorin expression patterns in the grasshopper limb bud.

Main Results:

Related Experiment Videos

  • Two semaphorins exhibit non-overlapping expression patterns within the developing grasshopper limb bud.
  • The combined action of these two semaphorins is essential for establishing the tibial sensory projection.

    • Conclusions:

    • A combinatorial action of semaphorins is critical for accurate axonal pathfinding.
    • A hierarchy of guidance cues likely directs sensory neuron development in the peripheral nervous system.