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Related Experiment Videos

An overview of structural genomics.

S K Burley1

  • 1Howard Hughes Medical Institute, Laboratories of Molecular Biophysics, The Rockefeller University, New York, New York 10021, USA. burley@rockefeller.edu

Nature Structural Biology
|December 5, 2000
PubMed
Summary
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Structural genomics uses genomic sequence data to determine protein structures. This initiative will generate vast amounts of structural data to accelerate biological discovery across many fields.

Area of Science:

  • Structural biology
  • Genomics
  • Bioinformatics

Background:

  • Advancements in sequencing technology provide unprecedented access to genomic data.
  • The complete human genome and genomes of model organisms are now available.
  • This wealth of sequence information is poised to revolutionize structural biology.

Purpose of the Study:

  • To initiate a systematic program in structural genomics.
  • To create a comprehensive catalog of protein structures.
  • To leverage genomic data for understanding biological systems.

Main Methods:

  • High-throughput X-ray crystallography.
  • Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Computational methods for comparative protein structure modeling.

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Main Results:

  • Generation of tens of thousands of experimental protein structures.
  • Calculation of millions of comparative protein structure models.
  • Establishment of a freely accessible, large-scale structural dataset.

Conclusions:

  • Structural genomics will provide a foundational resource for biological research.
  • The initiative promises to accelerate discoveries in diverse areas, including evolution, agriculture, and human health.
  • Freely available structural data will foster innovation across all life sciences.