Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrative database analysis in structural genomics.

M Gerstein1

  • 1Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06520, USA. Mark.Gerstein@yale.edu

Nature Structural Biology
|December 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What is bioinformatics? An introduction and overview.

Yearbook of medical informatics·2016
Same author

Novel transcribed regions in the human genome.

Cold Spring Harbor symposia on quantitative biology·2007
Same author

The geometry of the ribosomal polypeptide exit tunnel.

Journal of molecular biology·2006
Same author

Remodeling of hippocampal GABAergic system in adult offspring after maternal hypoxia and magnesium sulfate load: immunohistochemical study.

Experimental neurology·2005
Same author

Calculation of standard atomic volumes for RNA and comparison with proteins: RNA is packed more tightly.

Journal of molecular biology·2005
Same author

Identification of novel functional elements in the human genome.

Cold Spring Harbor symposia on quantitative biology·2004
Same journal

Fingering nucleic acids: the RNA did it.

Nature structural biology·2003
Same journal

Histone H1.2 as a trigger for apoptosis.

Nature structural biology·2003
Same journal

Tom40: more than just a channel.

Nature structural biology·2003
Same journal

Announcing the worldwide Protein Data Bank.

Nature structural biology·2003
Same journal

Small RNAs come of age.

Nature structural biology·2003
Same journal

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.

Nature structural biology·2003
See all related articles

Structural genomics integrates protein coordinate data with genomic information. Integrative database analysis reveals unique protein folds and structural features across various biological contexts.

Area of Science:

  • Structural biology
  • Genomics
  • Bioinformatics

Background:

  • Structural genomics aims to determine the 3D structures of all proteins.
  • Connecting structural data with functional and evolutionary information is crucial.
  • Existing databases often silo different types of biological data.

Purpose of the Study:

  • To explore the integration of structural data with diverse genomic information.
  • To develop methods for analyzing protein folds in a broader biological context.
  • To identify distinctive protein folds and structural motifs with significant biological relevance.

Main Methods:

  • Utilized integrative database analysis techniques.
  • Connected protein coordinate data with whole-genome information.

Related Experiment Videos

  • Surveyed protein fold characteristics from multiple biological perspectives.

    • Main Results:

    • Demonstrated the ability to link structural data with phylogenetic occurrence.
    • Showcased the connection between protein structure and gene expression patterns.
    • Highlighted specific protein folds and structural features that exhibit unique properties.

    Conclusions:

    • Integrative analysis is key for understanding protein structure-function relationships.
    • A comprehensive view of protein folds can be achieved by combining structural and genomic data.
    • This approach aids in identifying functionally or evolutionarily significant structural elements.