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Updated: Aug 7, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group Study
M A Hoffman1, J A Blessing, M Morgan
1Division of Hematology-Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
Objectives:
The objectives of this study were twofold: (1) to estimate the anti-tumor efficacy of CI-958 in patients with measurable platinum-resistant ovarian cancer; (2) to determine the nature and degree of toxicity of CI-958 in these patients.
Methods:
Patients received CI-958 560 mg/m(2) intravenously every 3 weeks and tumor measurements were performed every one to two cycles.
Results:
In 25 cases with recurrent platinum-resistant disease, there was one partial response (PR) and six patients had stable disease (SD).
Conclusions:
CI-958 has minimal activity in platinum-resistant ovarian cancer at the dose and schedule tested.
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