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Vectorcardiographic changes during cardioangiography with iodixanol and ioxaglate
1Department of Radiology, Göteborg University, Sahlgrenska University Hospital, S.E. 413 45, Göteborg, Sweden. agneta.flinck@xray.gu.se
International Journal of Cardiology
|December 6, 2000
Summary
Iodixanol contrast media caused fewer electrophysiological changes than ioxaglate during coronary angiography. Vectorcardiography effectively detected these differences, particularly during repolarization.
Area of Science:
- Cardiology
- Radiology
- Medical Imaging
Background:
- Contrast media (CM) are essential in coronary angiography.
- Assessing the electrophysiological effects of different CM is crucial for patient safety.
- Non-ionic dimers like iodixanol and ionic dimers like ioxaglate have distinct properties.
Purpose of the Study:
- To compare the electrophysiological effects of iodixanol and ioxaglate.
- To evaluate these effects using computerised dynamic vectorcardiography (VCG).
- To assess CM-induced changes during coronary angiography.
Main Methods:
- A double-blind, three-period crossover, randomised study.
- Comparison between iodixanol (320 mg I/ml) and ioxaglate (320 mg I/ml).
- VCG analysis of the first three left coronary artery injections.
Main Results:
- Significant differences in VCG variables between iodixanol and ioxaglate for five out of six parameters.
- Greater deviations from baseline observed with ioxaglate compared to iodixanol (P<0.05).
- Ioxaglate showed more pronounced effects on the ST-segment and T-wave.
Conclusions:
- Iodixanol induced less pronounced electrophysiological changes than ioxaglate.
- These differences were particularly notable during the repolarisation phase.
- VCG is a sensitive and reproducible method for detecting CM-induced electrophysiological effects.