Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protease Inhibitors Therapy for AIDS Patients.

Sommadossi1, Murphy

  • 1Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine; Birmingham, Alabama, USA.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|December 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rules for the Administration of Chloroform in Labor.

Iowa medical journal·2023
Same author

On Certain Forms of Headache.

The North-Western medical and surgical journal·2023
Same author

Twins Locked in Each Other.

The North-Western medical and surgical journal·2023
Same author

Report on the Use of Apomorphia in Sunstroke.

The Indian medical gazette·2017
Same author

Pharmacokinetic profile of rectally administered diclofenac sodium in children undergoing adenotonsillectomy

Paediatric anaesthesia·2000
Same author

Primary Generalized Epilepsies.

Current treatment options in neurology·2000
Same journal

Risk factors associated with invasive fungal disease post-liver transplantation.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
Same journal

Microbiome analysis of Cystic Fibrosis sputum presents higher sensitivity than the conventional bacterial culture.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
Same journal

Low awareness of HIV status and high proportion of recent infections among young travestis and trans women in Brazil.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
Same journal

Rare clinical presentations of paracoccidioidomycosis: Epidemiological, clinical, and microbiological insights from a Brazilian reference center.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
Same journal

Immunization against respiratory viruses among dental surgeons: high personal coverage, low involvement in vaccine promotion.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
Same journal

Is candidemia mortality inevitable or a consequence of inadequate guideline adherence?

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2026
See all related articles

Protease inhibitors significantly improve HIV treatment outcomes. Combining protease inhibitors with other antiretroviral agents increases CD4+ counts, reduces viral load, and lowers mortality rates in patients.

Area of Science:

  • Infectious Diseases
  • Virology
  • Pharmacology

Background:

  • HIV infection remains a significant global health challenge.
  • Protease inhibitors represent a key class of antiretroviral drugs.
  • Previous treatments for HIV have shown limitations in managing viral load and clinical progression.

Purpose of the Study:

  • To evaluate the clinical impact of protease inhibitors in HIV treatment.
  • To assess the efficacy of protease inhibitor-based regimens in both previously treated and untreated patients.
  • To explore different combination strategies involving protease inhibitors.

Main Methods:

  • Retrospective analysis of clinical data from HIV-infected patients.
  • Inclusion of patients receiving protease inhibitors as part of their antiretroviral therapy.

Related Experiment Videos

  • Evaluation of treatment outcomes including CD4+ cell counts, plasma viral burden, and clinical events.

    • Main Results:

    • Protease inhibitors significantly increase CD4+ cell counts in HIV patients.
    • Combination therapy including protease inhibitors leads to substantial decreases in plasma viral burden.
    • Regimens with protease inhibitors result in reduced rates of new clinical events and mortality.
    • Pilot studies show impressive efficacy and tolerance for various protease inhibitor combinations.

    Conclusions:

    • Protease inhibitors have a major clinical impact on HIV treatment.
    • Combination antiretroviral therapy including protease inhibitors is effective in managing HIV infection.
    • Further research into novel protease inhibitor combinations is warranted.