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Bone Paracoccidioidomycosis in an HIV-Positive Patient.
Miranda Aires E1, Costa Alves CA, Ferreira
1Institute of Infectology Emílio Ribas.
Summary
This study details a rare bone infection in an HIV-positive patient caused by Paracoccidioides brasiliensis. Moderate immunosuppression may lead to unique clinical presentations of paracoccidioidomycosis.
Area of Science:
- Mycology
- Infectious Diseases
- Immunology
Background:
- Acquired Immunodeficiency Syndrome (AIDS) patients are susceptible to opportunistic fungal infections.
- Infection with Paracoccidioides brasiliensis (PB) is rarely documented in patients with AIDS.
- Typical disseminated PB infections in HIV-positive individuals involve lymphatic and widespread disease.
Purpose of the Study:
- To report a novel clinical presentation of Paracoccidioides brasiliensis bone infection in an HIV-positive patient.
- To explore the relationship between the degree of immunosuppression and the clinical manifestation of paracoccidioidomycosis.
Main Methods:
- Case report of a single HIV-positive patient.
- Clinical and radiological assessment of a massive bone lesion.
- Evaluation of treatment response to medical and surgical interventions.
Main Results:
- The patient presented with a significant bone lesion as the primary manifestation of PB infection.
- Absence of typical lymphatic or disseminated disease commonly seen in AIDS patients with PB.
- Successful treatment outcome with combined medical and surgical management.
Conclusions:
- Patients with moderate immunosuppression may exhibit intermediate forms of paracoccidioidomycosis.
- This presentation differs from typical disseminated disease in severe AIDS and from infections in immunocompetent hosts.
- Highlights the importance of considering rare fungal infections in HIV-positive individuals with unusual presentations.
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