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An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
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Published on: October 6, 2015

Bone Paracoccidioidomycosis in an HIV-Positive Patient

Miranda Aires E1, Costa Alves CA, Ferreira

  • 1Institute of Infectology Emílio Ribas.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|December 6, 2000
PubMed

Insights

This study details a rare bone infection in an HIV-positive patient caused by Paracoccidioides brasiliensis. Moderate immunosuppression may lead to unique clinical presentations of paracoccidioidomycosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Acquired Immunodeficiency Syndrome (AIDS) patients are susceptible to opportunistic fungal infections.
  • Infection with Paracoccidioides brasiliensis (PB) is rarely documented in patients with AIDS.
  • Typical disseminated PB infections in HIV-positive individuals involve lymphatic and widespread disease.

Purpose of the Study:

  • To report a novel clinical presentation of Paracoccidioides brasiliensis bone infection in an HIV-positive patient.
  • To explore the relationship between the degree of immunosuppression and the clinical manifestation of paracoccidioidomycosis.

Main Methods:

  • Case report of a single HIV-positive patient.
  • Clinical and radiological assessment of a massive bone lesion.
  • Evaluation of treatment response to medical and surgical interventions.

Main Results:

  • The patient presented with a significant bone lesion as the primary manifestation of PB infection.
  • Absence of typical lymphatic or disseminated disease commonly seen in AIDS patients with PB.
  • Successful treatment outcome with combined medical and surgical management.

Conclusions:

  • Patients with moderate immunosuppression may exhibit intermediate forms of paracoccidioidomycosis.
  • This presentation differs from typical disseminated disease in severe AIDS and from infections in immunocompetent hosts.
  • Highlights the importance of considering rare fungal infections in HIV-positive individuals with unusual presentations.

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