Related Experiment Video
Updated: Oct 8, 2026

16:24
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Clinical use of selective estrogen receptor modulators
1University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Stratford, USA. krueger@umdnj.edu
The Journal of the American Osteopathic Association
|December 6, 2000
Abstract:
Selective estrogen receptor modulators (SERMs) are an exciting category of drugs for physicians providing healthcare to women. This article explores their pharmacology, effects on target organs and clinical effectiveness.
More Related Videos
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Dose-Response Relationship: Selectivity and Specificity
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...

