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One 25 day survivor with total artificial heart
The Journal of Thoracic and Cardiovascular Surgery
|January 1, 1975
Summary
A calf supported by a total artificial heart (TAH) survived for 25 days, demonstrating stable hemodynamics and organ function. This study highlights the potential of TAH for clinical applications and physiological research.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Surgical Innovation
Background:
- Total artificial heart (TAH) technology is crucial for end-stage heart failure treatment.
- Assessing TAH performance in large animal models is vital for clinical translation.
Purpose of the Study:
- To evaluate the short-term efficacy and physiological impact of an orthotopically implanted TAH in a calf model.
- To determine the feasibility of TAH for supporting circulation and enabling physiological studies.
Main Methods:
- An 87 kg calf received an orthotopic TAH implantation.
- Hemodynamic parameters, including cardiac output and right atrial pressure, were monitored.
- Kidney and pulmonary functions were assessed, alongside signs of infection and organ damage.
Main Results:
- The calf survived for 25 days with sustained cardiac output (8.0-11.0 L/min).
- Normal kidney and pulmonary function were maintained; however, right atrial pressure increased terminally.
- Infection and potential organ damage were noted but managed, with the calf remaining active.
Conclusions:
- The study demonstrates the feasibility of TAH implantation for short-term circulatory support in a large animal model.
- TAH use is viable for immediate application in cardiovascular physiology and pharmacology research.
- Cerebral thromboembolism was the cause of death, indicating a need for anticoagulation strategies.