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Serum creatinine can predict adequacy of peritoneal dialysis--preliminary report
C M Stirling1, K Simpson, M Boulton-Jones
1Renal Unit, Royal Infirmary, Glasgow, Scotland.
Aim:
To determine the value of creatinine clearance, estimated using the Cockcroft and Gault formula, in assessing adequacy of peritoneal dialysis.
Methods:
We undertook a retrospective analysis of creatinine clearance results derived from a conventional 24-hour collection in 35 stable outpatients on peritoneal dialysis and compared them with those calculated from the corresponding serum creatinine using the Cockcroft and Gault formula.
Results:
There was a strong correlation between the 2 methods (r = 0.82, p < 0.0001), although the formula tended to over-estimate clearances. The formula had a positive predictive value of 88% and a negative predictive value of 86% for detecting inadequate dialysis.
Conclusion:
The creatinine clearance calculated using the Cockcroft and Gault formula can be used in patients on peritoneal dialysis to estimate adequacy of dialysis. We believe that this method, which is far less expensive and time-consuming, deserves further testing in a larger population in order to define more accurately its role in the management of PD patients.