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Role of Cbfa1 in osteoblast differentiation and function
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX 77030, USA.
Seminars in Cell & Developmental Biology
|December 6, 2000
Abstract:
Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.