Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Function of CBFbeta/Bro proteins.

N Adya1, L H Castilla, P P Liu

  • 1Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.

Seminars in Cell & Developmental Biology
|December 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Correlation between ABO Blood Types and Alcoholic Liver Disease.

Clinical laboratory·2025
Same author

[The status and changing trend in the burden of refractive errors in China from 1990 to 2019].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2024
Same author

[EBF1 Promotes the Sensitivity of Cervical Cancer Cells to Cisplatin via Activating FBN1 Transcription].

Molekuliarnaia biologiia·2023
Same author

Small intestinal morphology and sugar transporters expression when consuming diets of different energy levels: comparison between Tibetan and small-tailed Han sheep.

Animal : an international journal of animal bioscience·2022
Same author

[Eosinophilic solid and cystic renal cell carcinoma with tumor-induced osteomalacia: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2021
Same author

Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.

Blood·2021

Core binding factor beta (CBFbeta) is a crucial transcription factor for hematopoiesis and development. Mutations in the CBFB gene are linked to acute myeloid leukemia, suggesting broader roles in other organ systems.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Core binding factor beta (CBFbeta) and its Drosophila homologs (Brother and Big-brother) are key transcription factors.
  • These proteins dimerize with Runx/Runt/Lozenge family members, enhancing DNA binding and transcriptional activity.
  • CBFbeta is vital for definitive hematopoiesis during mouse embryogenesis.

Purpose of the Study:

  • To investigate the role of CBFbeta in mammalian and Drosophila development.
  • To explore the involvement of CBFbeta in leukemogenesis.
  • To understand the broader implications of CBFbeta's ubiquitous expression pattern.

Main Methods:

  • Comparative analysis of CBFbeta, Brother, and Big-brother protein functions.
  • Examination of CBFbeta's role in hematopoiesis using mouse models.

Related Experiment Videos

  • Analysis of CBFB gene mutations in acute myeloid leukemia patients.

    • Main Results:

    • CBFbeta is essential for the development and maintenance of definitive hematopoiesis.
    • Drosophila Brother and Big-brother proteins are required for Runt/Lozenge functions in development.
    • The CBFB gene is consistently mutated in acute myeloid leukemia subtype M4Eo due to a specific chromosome 16 inversion.

    Conclusions:

    • CBFbeta plays a critical role in hematopoiesis and development.
    • CBFbeta's involvement in leukemogenesis highlights its significance in cancer biology.
    • The widespread expression of CBFB suggests potential roles in various other organ systems beyond hematopoiesis.