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TNF-alpha, leptin, and lymphocyte function in human aging.

H Bruunsgaard1, A N Pedersen, M Schroll

  • 1Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark. infdishb@rh.dk

Life Sciences
|December 6, 2000
PubMed
Summary
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Aging immune function declines, with higher tumor necrosis factor-alpha (TNF-alpha) linked to reduced T cell activity. This study found TNF-alpha, not leptin, associated with immune changes in older adults.

Area of Science:

  • Immunology
  • Gerontology

Background:

  • Aging is characterized by increased inflammation and diminished T cell immunity.
  • Leptin's role in linking inflammation and T cell function during aging is unclear.

Purpose of the Study:

  • To investigate the association between plasma tumor necrosis factor-alpha (TNF-alpha) levels and leptin, soluble interleukin-2 receptors (sIL-2R), and phytohemagglutinin (PHA)-stimulated IL-2 production in elderly individuals.

Main Methods:

  • Compares elderly (N=42) and young (N=37) control groups.
  • Measures plasma TNF-alpha, sIL-2R, leptin, and PHA-induced IL-2 production.
  • Utilizes univariate and multiple linear regression analyses, adjusting for gender and BMI.

Main Results:

  • Elderly individuals exhibit higher TNF-alpha and sIL-2R levels than young controls.

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  • No age-related differences in IL-2 production or leptin levels were observed; women had higher leptin.
  • In the elderly, TNF-alpha correlated positively with sIL-2R and negatively with IL-2 production, but leptin did not show these associations.

    • Conclusions:

    • Elevated TNF-alpha in aging is associated with impaired ex vivo IL-2 production and in vivo lymphocyte activation.
    • Leptin does not appear to mediate the relationship between TNF-alpha and immune dysfunction in aging.