Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do antidepressants selectively suppress spontaneous (unexpected) panic attacks? A replication.

E H Uhlenhuth1, W Matuzas, T D Warner

  • 1Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque 87131, USA. uhli@unm.edu

Journal of Clinical Psychopharmacology
|December 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the potential of a discrete titania chemiresistor: broad-spectrum sensing of C1-C4 alcohols and precise C3 isomer discrimination in binary mixtures.

Nanoscale·2025
Same author

Kinetic Modelling and Machine Learning Approaches on the Conductance Transients of Zn<sub>0.5</sub>Ni<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> Sensors for Addressing Cross-sensitivity towards Ethanol and Acetone Vapors.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia.

AJNR. American journal of neuroradiology·2021
Same author

Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge.

Nutrition research reviews·2019
Same author

Evaluating sub-typing methods for pathogenic Yersinia enterocolitica to support outbreak investigations in New Zealand.

Epidemiology and infection·2019
Same author

Safety of resuming anti-PD-1 in patients with immune-related adverse events (irAEs) during combined anti-CTLA-4 and anti-PD1 in metastatic melanoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same journal

Are the 8 Finnish Deaths Explained by Agranulocytosis More Important than the Thousands of Suicide Deaths Associated with the Lack of Use of Clozapine? Reflections on Clozaphobia.

Journal of clinical psychopharmacology·2026
Same journal

Aripiprazole Withdrawal-Associated Restless Legs Syndrome During Clozapine Treatment in an Adolescent With Schizoaffective Disorder: A Case Report.

Journal of clinical psychopharmacology·2026
Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026
Same journal

Article Selected to Receive the Mitchell B. Balter Award for Publications in 2025.

Journal of clinical psychopharmacology·2026
Same journal

Pregnancy Outcomes After First-Trimester Exposure to Vortioxetine: Prospective Outcomes From the MGH National Pregnancy Registry for Psychiatric Medications.

Journal of clinical psychopharmacology·2026
Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026
See all related articles

This study found that fluoxetine effectively reduces spontaneous panic attacks in patients with panic disorder, supporting hypotheses about the disorder's biological and cognitive components and their differential treatment responses.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Panic disorder is hypothesized to have distinct biological (spontaneous panic attacks) and cognitive (situational attacks, phobias) components.
  • These components may respond differently to therapeutic interventions.
  • The Law of Initial Value suggests biological processes may respond to treatment proportionally to their baseline deviation.

Purpose of the Study:

  • To test hypotheses regarding the pathogenesis and treatment of panic disorder using a larger dataset.
  • To replicate and extend previous findings on imipramine's effects on panic disorder components.
  • To investigate the dose-dependent effects of fluoxetine on spontaneous and situational panic attacks and agoraphobia.

Main Methods:

  • A multicenter, double-blind study involving patients with panic disorder treated with placebo, fluoxetine 10 mg, or fluoxetine 20 mg for 10 weeks.

Related Experiment Videos

  • Patients recorded spontaneous and situational panic attacks daily; agoraphobia was rated at visits.
  • Pre- and post-treatment data were analyzed using regression slopes to compare treatment effects.

    • Main Results:

    • Fluoxetine demonstrated a statistically significant, dose-dependent suppressive effect on spontaneous panic attacks.
    • No significant drug effects were observed on situational panic attacks.
    • A therapeutic effect on agoraphobia was suggested at the lower fluoxetine dose (10 mg) but not the higher dose (20 mg).

    Conclusions:

    • Results support the hypotheses that panic disorder has distinct components responding differently to treatment.
    • Antidepressant effects in panic disorder may stem primarily from suppressing spontaneous panic attacks.
    • Findings have implications for understanding panic disorder pathogenesis, clinical practice, and future research.