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Results of the cooperative protocol (N-III-95) for metastatic relapses and refractory neuroblastoma
1Unidad de Oncología Pediátrica, Hospital Infantil La Fe, Valencia, Spain.
Background:
Prognosis of relapsed and refractory neuroblastoma is uniformly fatal; new therapeutic approaches are needed.
Procedure:
Relapsed and refractory neuroblastoma patients were treated with continuous infusion chemotherapy combined with MIBG.
Results:
Over 4 years, 35 heavily pretreated patients were registered, 29 with bone or/and bone marrow metastases. Grade 3 or 4 hematologic toxicity was frequent, without toxic deaths. Sixteen patients responded. The probability of 5-year overall survival was 0.19.
Conclusions:
This approach is feasible and toxicity manageable; it rescued some patients and prolonged their survival. It merits assay in newly diagnosed high-risk neuroblastoma patients.