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Updated: Oct 10, 2026

Laparoscopic Pyeloplasty via Transmesenteric Approach for Pediatric Ureteropelvic Junction Obstruction
Published on: July 7, 2026
[Long-term follow-up of children with surgically treated primary vesicouretral reflux]
Y Sugita1, S Tanikaze, S Kamidono
1Department of Urology, Kobe Children's Hospital.
Insights
This study on surgically treated primary vesicoureteral reflux found hypertension and proteinuria were rare in patients over 15. Long-term follow-up is crucial for those with severe reflux treated early.
Area of Science:
- Pediatric Urology
- Nephrology
- Surgical Outcomes
Background:
- Primary vesicoureteral reflux (VUR) is a common condition in children.
- Surgical intervention is a primary treatment for VUR.
- Long-term renal outcomes after VUR surgery require continued investigation.
Purpose of the Study:
- To evaluate renal function, hypertension, and proteinuria in adult patients (≥15 years) who underwent surgical treatment for primary VUR.
- To identify factors influencing renal function post-VUR surgery.
Main Methods:
- Retrospective review of 22 patients aged 15 and over with surgically treated primary VUR.
- Assessment of hypertension and proteinuria.
- Evaluation of renal function using the extraction factor by Heyman's method.
- Analysis of the relationship between age at operation, reflux grade, and extraction factor.
Main Results:
- Only one patient presented with proteinuria; no patients had hypertension.
- The extraction factor tended to increase with older age at operation.
- The extraction factor tended to decrease with a higher grade of reflux at operation.
Conclusions:
- Hypertension and proteinuria appear uncommon in adults with a history of surgically treated primary VUR.
- Severe reflux and early surgical intervention may necessitate extended long-term patient monitoring.
- The findings underscore the importance of vigilant long-term follow-up for specific patient cohorts post-VUR surgery.
Abstract:
We reviewed the symptoms of hypertension and proteinuria and evaluated the renal function in patients aged 15 and over with surgically treated primary vesicoureteral reflux. Twenty-two patients were enrolled in this study. There were no patients with hypertension except one patient with proteinuria. The extraction factor by Heyman's method in these patients tended to increase with age at operation and decrease with the grade of reflux at operation. There findings suggest that long-term follow-up is particularly essential to patients who had severe reflux and underwent anti-reflux surgery in the early stage of life.
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