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[Plesiomonas shigelloides, a Vibrionaceae to be taken into account]
Abstract:
The antigenic structure and antimicrobial susceptibility were studied in 99 strains isolated from patients with acute diarrhea (6 strains from an outbreak of digestive transmission disease in Santiago de Cuba) and a strain isolated from a patient who died from infections neurological syndrome (INS, meningitis). Four new serotypes (093, 994, 095, 096), which had not been described in the world classification, were identified from the Cuban isolated strains and were included in the International Serotyping Scheme by the International Reference Center located in Prague, Czech Republic. For the first time in Cuba, the circulation of serotypes 017:H11, 011: H2, 023. H1alc, 057: H3 which show cross reaction to Shiguella species was proved. Those strains from the outbreak of digestive disease belonged to serotype 050: H11 and had a thermostable toxin. The first case of infectious neurologic syndrome with Plesionomas shigelloides etiology reported in Cuba was described; the strain corresponded to serotype 050: H11. The worldwide reported pattern of antimicrobial resistance was demonstrated.
Insights
This study identified four new Plesiomonas shigelloides serotypes from Cuban patients and confirmed the presence of specific serotypes linked to diarrhea and infectious neurologic syndrome (INS). Antimicrobial resistance patterns align with global trends.
Area of Science:
- Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Plesiomonas shigelloides is an emerging pathogen causing gastrointestinal and extraintestinal infections.
- Understanding its antigenic diversity and antimicrobial susceptibility is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize the antigenic structure and antimicrobial susceptibility of Plesiomonas shigelloides strains isolated in Cuba.
- To identify novel serotypes and investigate the epidemiology of Plesiomonas shigelloides infections, including infectious neurologic syndrome.
Main Methods:
- Serotyping of 99 Plesiomonas shigelloides strains using the International Serotyping Scheme.
- Antimicrobial susceptibility testing.
- Clinical data review for cases of acute diarrhea and infectious neurologic syndrome.
Main Results:
- Four novel serotypes (O93, O94, O95, O96) were identified and added to the International Serotyping Scheme.
- Serotypes O17:H11, O11:H2, O23:H1a, and O57:H3, showing cross-reactivity with Shigella, were detected in Cuba for the first time.
- Outbreak strains belonged to serotype O50:H11 and produced a thermostable toxin.
- The first reported case of infectious neurologic syndrome caused by Plesiomonas shigelloides in Cuba was linked to serotype O50:H11.
- Observed antimicrobial resistance patterns were consistent with worldwide trends.
Conclusions:
- The study expanded the Plesiomonas shigelloides serotype classification with novel Cuban strains.
- Plesiomonas shigelloides serotype O50:H11 was identified as a cause of both acute diarrhea and infectious neurologic syndrome in Cuba.
- The findings highlight the importance of ongoing surveillance for Plesiomonas shigelloides epidemiology and resistance patterns.