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Updated: Jul 14, 2026
10:26
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 12, 2014
[Human papillomavirus as a risk factor in carcinogenesis]
1Avdeling for patologi, Det Norske Radiumhospital, Oslo. agnes-kathrine.lie@labmed.uio.no
Summary
Human papillomavirus (HPV) is a necessary cause of cervical cancer. While HPV is linked to other anogenital and upper digestive tract cancers, its role is still being investigated.
Area of Science:
- Oncology
- Virology
- Epidemiology
Context:
- The causal link between Human papillomavirus (HPV) and cervical neoplasia is well-established.
- HPV 16 and 18 were classified as human carcinogens in 1995.
- This paper reviews the etiological role of HPV in various cancers.
Purpose:
- To discuss the etiological role of HPV infection in carcinomas of the anogenital region, respiratory, and upper digestive tract.
- To review the current understanding of HPV's role in carcinogenesis based on literature and author's research.
Summary:
- HPV is a necessary, though not sufficient, factor in cervical carcinogenesis.
- Nearly all cervical carcinomas and precursor lesions are HPV-positive.
- HPV-DNA is prevalent in other anogenital region carcinomas, but not significantly in prostate cancer.
- Emerging evidence suggests HPV may be a risk factor in respiratory and upper digestive tract cancers, requiring further proof.
Impact:
- Therapeutic and prophylactic HPV vaccines are under development.
- Vaccines may significantly impact the treatment and prevention of cervical carcinomas globally.
- Further research is needed to confirm HPV's role in respiratory and upper digestive tract carcinogenesis.
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