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Updated: Aug 15, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression
L M Khachigian1, Y Takuwa, T Collins
1Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney, Australia.
Abstract:
Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall. This review is concerned with recent developments in our understanding of the signaling and transcriptional mechanisms mediating the inducible expression of one vasoconstrictor by another.
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