Efficient sampling in 3-D stereologic volumetry

Present 3-D stereology techniques use fixed grid sampling where the sampling grid of test points is randomly placed in 3-D. In order to increase randomness of sampling, in this paper we propose random grid sampling scheme where grid sections are placed randomly over 2-D cross-sections. A random grid sampler has superior efficiency and accuracy compared with fixed grid sampling. Using MR head scans we demonstrate the use of random grid sampling in volumetry of structures in 3-D biomedical images.