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Migrating partial seizures in infancy: two new cases.

J M Wilmshurst1, D B Appleton, P J Grattan-Smith

  • 1Neurology Department, The New Children's Hospital, Sydney, Australia.

Journal of Child Neurology
|December 7, 2000
PubMed
Summary
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Migrating partial seizures in infancy are a rare, severe epilepsy syndrome. This study describes two infants with this condition, highlighting their intractable seizures and poor outcomes.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neuroscience

Background:

  • Intractable partial seizures in infants pose significant diagnostic and therapeutic challenges.
  • Early-onset epilepsy syndromes require precise characterization for appropriate management.
  • The syndrome of migrating partial seizures in infancy (MPSI) is a rare, severe condition.

Observation:

  • Two infants presented with intractable partial seizures originating from multiple brain regions.
  • Seizures were resistant to all antiepileptic drug therapies.
  • No developmental progress was observed after seizure onset.

Findings:

  • Both infants exhibited multifocal epileptiform activity on electroencephalograms.
  • The clinical presentation and EEG findings met the diagnostic criteria for MPSI.

Related Experiment Videos

  • Postmortem examination in one infant revealed no hippocampal sclerosis.

    • Implications:

    • This case study underscores the diagnostic criteria and clinical course of MPSI.
    • Further research is needed to understand the etiology and pathophysiology of MPSI.
    • Improved diagnostic and therapeutic strategies are crucial for infants with MPSI.