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Updated: Jul 26, 2026
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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
Growth and development in patients with untreated clefts
1Department of Growth and Development, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. lwill@hms.harvard.edu
Summary
Individuals with cleft lip and palate show distinct facial growth patterns. This review synthesizes current knowledge on dentofacial morphology in untreated cleft patients, highlighting future challenges in cleft care.
Area of Science:
- Craniofacial biology
- Orthodontics
- Pediatric dentistry
Background:
- Individuals with cleft lip and palate (CLP) exhibit altered facial growth compared to non-cleft individuals.
- Dentofacial morphology assessments are crucial for understanding these growth differences.
- Existing research provides insights into the unique developmental trajectories in CLP populations.
Purpose of the Study:
- To review the current understanding of facial growth in patients with untreated clefts.
- To synthesize the state of the art regarding dentofacial morphology in CLP.
- To identify future challenges and directions for cleft care.
Main Methods:
- Literature review of studies on facial growth and dentofacial morphology in untreated cleft patients.
- Synthesis of findings to establish the current state of knowledge.
- Identification of research gaps and clinical implications.
Main Results:
- Cleft lip and palate significantly impact craniofacial development, leading to specific dentofacial morphology.
- Variability in growth patterns exists within the cleft population.
- Understanding these patterns is key to effective management.
Conclusions:
- A comprehensive understanding of facial growth in untreated clefts is essential.
- Future cleft care must address the complexities of dentofacial morphology.
- Further research is needed to refine treatment strategies for improved outcomes.
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