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Related Experiment Videos

Diffusion tensor MRI of the spinal cord.

M Ries1, R A Jones, V Dousset

  • 1Résonance Magnetique des Systemes Biologiques, UMR 5536, CNRS/Université Bordeaux2, Bordeaux, France.

Magnetic Resonance in Medicine
|December 7, 2000
PubMed
Summary

Apparent diffusion tensor (ADT) measurements using pulsed-field-gradient (PFG) echo-planar imaging (EPI) reveal significant spinal cord anisotropy. This technique robustly detects diffusion changes, even when conventional imaging fails.

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Diffusion tensor imaging (DTI) is crucial for assessing white matter integrity.
  • Spinal cord DTI presents unique challenges due to motion and anatomical complexity.
  • Pulsed-field-gradient (PFG) techniques offer advanced diffusion measurements.

Purpose of the Study:

  • To present apparent diffusion tensor (ADT) measurements of the spinal cord using a PFG multi-shot EPI sequence.
  • To compare rotationally invariant anisotropy information with rotationally dependent methods.
  • To evaluate the clinical applicability of ADT measurements in spinal pathologies.

Main Methods:

  • Utilized a pulsed-field-gradient (PFG) multi-shot echo-planar imaging (EPI) sequence for spinal cord ADT measurements.

Related Experiment Videos

  • Studied 10 healthy volunteers to characterize normal diffusion properties.
  • Investigated 10 patients with cervical canal stenosis to assess diffusion changes in pathology.

    • Main Results:

    • Demonstrated significantly higher water diffusivity parallel (approx. 2.5x) to spinal cord fibers compared to perpendicular directions.
    • Observed cylindrically symmetric anisotropy characteristics in the spinal cord.
    • Determined that a resolution of 1 mm in read and phase directions is necessary for unbiased ADT values.
    • Showed that ADT changes in cervical canal stenosis were detectable even when conventional T1/T2 weighted imaging showed no lesion.

    Conclusions:

    • Spinal cord diffusion exhibits pronounced anisotropy, measurable with PFG-EPI ADT.
    • High-resolution ADT imaging can robustly detect subtle spinal cord pathologies.
    • This technique holds promise for improved clinical diagnosis of spinal cord diseases.