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High proinsulin levels precede first-ever stroke in a nondiabetic population
B Lindahl1, B Dinesen, M Eliasson
1Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. bernt.lindahl@medicin.umu.se
Stroke
|January 11, 2000
Summary
High proinsulin levels significantly increase stroke risk in non-diabetics. This finding highlights proinsulin as a potential predictor for first-ever stroke, especially in women.
Area of Science:
- Endocrinology
- Neurology
- Cardiovascular Medicine
Background:
- Diabetes elevates stroke risk by 3-6 fold.
- Hyperinsulinemia is linked to cardiovascular risk factors.
- Proinsulin shows stronger cardiovascular disease associations than insulin.
Purpose of the Study:
- To evaluate associations between first-ever stroke, proinsulin, and insulin.
- To investigate stroke risk predictors in a non-diabetic population.
Main Methods:
- Incident case-referent study design.
- 94 first-ever stroke cases matched with 178 referents.
- Blood samples collected pre-stroke, proinsulin and insulin measured via ELISA.
Main Results:
- High proinsulin (>3x) elevated stroke risk (OR 3.4).
- Risk was more pronounced in women (OR 13.7).
- Synergistic effects found between proinsulin and blood pressure.
Conclusions:
- Elevated proinsulin levels may predict future stroke in non-diabetics.
- Proinsulin is a significant risk factor for first-ever stroke.