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A tape-stripping method for measuring dermal exposure to multifunctional acrylates
1Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, NC 27599, Chapel Hill, USA. leena_french@unc.edu
The Annals of Occupational Hygiene
|December 8, 2000
Summary
A new tape-stripping method effectively measures dermal exposure to acrylates, like tripropylene glycol diacrylate (TPGDA). This noninvasive technique quantifies skin exposure, overcoming limitations of current methods for irritant and allergen assessment.
Area of Science:
- Occupational Health
- Dermatology
- Analytical Chemistry
Background:
- Current methods for assessing dermal exposure to acrylates have significant limitations.
- Acrylates are common skin irritants and allergens in occupational settings.
Purpose of the Study:
- To develop and validate a noninvasive tape-stripping method for quantifying dermal exposure to multifunctional acrylates.
- To assess the efficiency of tape stripping for measuring exposure to tripropylene glycol diacrylate (TPGDA) and UV-curable acrylate coatings.
Main Methods:
- Developed a tape-stripping technique to collect samples from the nonviable epidermis (stratum corneum).
- Employed gas chromatography for quantitative analysis of TPGDA.
- Tested the method on 10 human volunteers exposed to TPGDA or a UV-resin containing TPGDA.
Main Results:
- The first tape stripping recovered an average of 94% of TPGDA and 89% of TPGDA in UV-resin within 30 minutes.
- Two consecutive tape strippings accounted for nearly all deposited TPGDA, demonstrating method efficiency.
- No significant differences in recovery were observed between TPGDA and UV-resin for the first tape stripping.
Conclusions:
- The tape-stripping technique is an efficient and noninvasive method for quantifying dermal exposure to multifunctional acrylates.
- This method has potential for determining the rate of dermal absorption over time.
- The findings support the use of tape stripping for improved exposure assessment of acrylate-related skin hazards.