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Related Experiment Videos

Modulation of polymorphonuclear leukocytes function by nitric oxide.

S Sethi1, M Dikshit

  • 1Pharmacology Division, Central Drug Research Institute, -226001,., Lucknow, India.

Thrombosis Research
|December 8, 2000
PubMed
Summary
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Nitric oxide (NO) is synthesized by various cells, including polymorphonuclear leukocytes (PMNs). This review explores the modulatory role of NO on PMN functions and its implications in health and disease.

Area of Science:

  • Physiology
  • Biochemistry
  • Immunology

Background:

  • Nitric oxide (NO) was initially recognized as an endothelium-derived factor, but is now known to be synthesized by various cells via nitric oxide synthase (NOS).
  • Inflammatory cytokines can induce inducible NOS (iNOS) in somatic cells, and blood cells like polymorphonuclear leukocytes (PMNs) also synthesize NO.
  • PMNs are significant participants in pathological conditions where NO is implicated, synthesizing NO at rates comparable to endothelial cells.

Purpose of the Study:

  • To review the modulatory role of NO on PMN functions.
  • To highlight discrepancies regarding NOS presence in PMNs.
  • To underscore the importance of PMN-derived NO in physiological and pathological contexts.

Main Methods:

  • Literature review focusing on nitric oxide synthase (NOS) in polymorphonuclear leukocytes (PMNs).

Related Experiment Videos

  • Analysis of existing studies on peripheral PMNs and limited data on emigrated PMNs.
  • Synthesis of information on the regulatory role of PMN-NOS in cellular functions.

    • Main Results:

    • PMNs synthesize NO, with potential significance in various physiological and pathological conditions.
    • Discrepancies exist regarding the presence and activity of NOS in PMNs.
    • Limited research exists on emigrated PMNs compared to peripheral PMNs.

    Conclusions:

    • Understanding PMN-derived NO is crucial for comprehending its role in health and disease.
    • Further systematic studies on PMNs from different sources are warranted.
    • NO plays a significant modulatory role in PMN functions, necessitating further investigation into PMN-NOS.