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Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis
C Ballerini1, D Campani, G Rombolà
1Department of Neurological and Psychiatrical Sciences, University of Florence, Viale Pieraccini 6, 50134, Florence, Italy. neuroimm@cesit1.unifi.it
Neuroscience Letters
|December 8, 2000
Abstract:
In this study we investigated the distribution of apolipoprotein E (APO E) genotypes in sporadic multiple sclerosis (MS) cases and in normal controls. Later onset of chronic progressive MS was observed in patients carrying the epsilon2 allele, whereas APO E alleles were found at similar frequency in MS and in the control population. These findings indicate that clinical heterogeneity, but probably not susceptibility to the disease, is associated to APO E genotypes.