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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
[Is a totally non-invasive assessment of the hemodynamic profile possible in patients with chronic heart failure?]
F L Dini1, G P Bezante, P Faggiano
1Unità Operativa di Cardiologia, Ospedale Villamarina, Piombino (LI).
Insights
Doppler echocardiography offers noninvasive hemodynamic assessment for cardiac patients, aiding in pressure and output measurements. Contrast agents may enhance signal accessibility, expanding its clinical utility.
Area of Science:
- Cardiology
- Medical Imaging
- Hemodynamics
Context:
- Doppler echocardiography is increasingly used to assess cardiac hemodynamics.
- Accurate measurement of left ventricular filling pressure and cardiac output is crucial for managing cardiac diseases.
- Noninvasive hemodynamic assessment complements traditional methods like right heart catheterization.
Purpose:
- To review the capabilities and limitations of Doppler echocardiography in assessing cardiac hemodynamics.
- To highlight the validation of Doppler-derived hemodynamic indices against invasive measurements.
- To discuss the potential of Doppler echocardiography in identifying hemodynamic subsets, particularly in acute myocardial infarction.
Summary:
- Doppler echocardiography enables comprehensive hemodynamic assessment, including left ventricular filling pressures and cardiac output, validated against right heart catheterization.
- Pulmonary artery pressures can be measured noninvasively using Doppler-derived gradients across cardiac valves.
- Contrast agents can improve signal acquisition, broadening the application of noninvasive hemodynamic assessment.
Impact:
- Doppler echocardiography provides a noninvasive alternative for hemodynamic evaluation in various cardiac conditions.
- The technique aids in identifying distinct hemodynamic profiles in patients, such as those with acute myocardial infarction.
- Despite challenges like operator dependency, advancements like contrast enhancement promise wider clinical adoption.
Abstract:
Relevant hemodynamic information can be obtained by a comprehensive Doppler echocardiographic examination in patients with various cardiac diseases. The assessment of left heart hemodynamics by Doppler echocardiography has been addressed by several investigators. The feasibility and the accuracy of methods for the estimation of left ventricular filling pressure and cardiac output have been validated by comparative right heart catheterization. Studies have shown that Doppler echocardiography can allow the measurement of pulmonary artery pressures from the pressure gradients across the tricuspid and pulmonary valves. The possibility of completely characterizing cardiac hemodynamics noninvasively has recently been documented: in patients with acute myocardial infarction, automated cardiac output measurement along with the assessment of left ventricular filling by Doppler echocardiography may be used for the identification of hemodynamic subsets. Although Doppler echocardiography can provide noninvasive measures of hemodynamic indices, its value has been disputed since the technique is patient-dependent, time-consuming and requires meticulous acquisition and interpretation by skilled operators. The use of contrast agents may improve the accessibility of both right-sided and left-sided Doppler signals, potentially increasing the number of patients to whom the noninvasive hemodynamic assessment could be applied.
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