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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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Relationship between the isoniazid-resistant mutation katGS315T and the prevalence of MDR-/XDR-TB in Osaka, Japan.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2008
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Dialogue between Mycobacterium tuberculosis and Homo sapiens Part II A long-term truce between multidrug-resistant mycobacteria and a TB patient.

Tuberculosis (Edinburgh, Scotland)·2002
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[Comparison of the newly developed MYCOACID system with mycobacteria growth indicator tube (MGIT) and newly developed 2% Ogawa medium (S) for recovery of mycobacteria in clinical specimens].

Kekkaku : [Tuberculosis]·2002
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Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells.

The Journal of rheumatology·2001
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Dialogue between Mycobacterium tuberculosis and Homo sapiens.

Tuberculosis (Edinburgh, Scotland)·2001
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[Immunological status of tuberculosis].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·2000

Related Experiment Video

Updated: Jul 15, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

[Riddles in human tuberculous infection].

I Tsuyuguchi1

  • 1Osaka Prefectural Habikino Hospital, Japan.

Kekkaku : [Tuberculosis]
|December 8, 2000
PubMed
Summary

Tuberculosis (TB) infection involves Mycobacterium tuberculosis persistence. Understanding TB pathogenesis and developing a better vaccine requires an accurate animal model and insights into the mycobacterial cell wall

Area of Science:

  • Immunology and infectious diseases, focusing on Mycobacterium tuberculosis.
  • Microbial pathogenesis and host-pathogen interactions.

Context:

  • Tuberculosis (TB) remains a significant global health challenge, caused by Mycobacterium tuberculosis.
  • Most infected individuals remain asymptomatic, with dormant bacilli persisting for years, posing diagnostic and therapeutic enigmas.
  • Current understanding of TB pathogenesis, dormancy, reactivation, and effective vaccination strategies is incomplete.

Purpose:

  • To highlight critical unanswered questions in the natural history of Mycobacterium tuberculosis infection in humans.
  • To emphasize the urgent need for an appropriate animal model that accurately reflects human TB.
  • To explore the role of the mycobacterial cell wall, specifically cord factor (trehalose dimycolate), in TB pathogenesis and host immune response.

Summary:

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Jul 15, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

  • Key enigmas in TB include the mechanisms of virulence, dormancy, disease development, and endogenous reactivation.
  • The current murine model inadequately represents human TB, hindering research progress.
  • Mycobacterial cell wall components, like cord factor (TDM), are implicated in pathogenesis not through direct toxicity but via excessive host immune stimulation (cytokine production, TNF-alpha).

Impact:

  • Addressing these research gaps, particularly through improved animal models, is crucial for developing more potent anti-TB vaccines than BCG.
  • Understanding how to mitigate the detrimental immune effects of mycobacterial cell wall components is vital for future vaccine development.
  • This research aims to advance TB control strategies by unraveling complex host-pathogen interactions.