Related Experiment Video
Updated: Jul 8, 2026

10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Perianal streptococcal dermatitis]
A L Souillet1, F Truchot, D Jullien
1Clinique dermatologique et vénéréologique, hôpital Edouard-Herriot, place d'Arsonval, Lyon, France.
Summary
Pediatric perianal streptococcal dermatitis (PSD) is often missed by doctors. Early diagnosis and amoxicillin treatment are key to resolving this common streptococcal skin infection.
Area of Science:
- Pediatric Dermatology
- Infectious Diseases
Background:
- Pediatric perianal streptococcal dermatitis (PSD) is a distinct condition.
- Despite its clear presentation, PSD is frequently overlooked by healthcare providers.
Observation:
- A case study details a seven-year-old girl with a three-week history of perianal and vulvar redness, pain, and constipation.
- The patient also had a sore throat and perioral impetigo, initially treated unsuccessfully for a suspected fungal infection.
Findings:
- Group A beta-hemolytic streptococci were identified in perirectal and perioral swabs, confirming the PSD diagnosis.
- Amoxicillin treatment led to rapid clearance of perianal lesions within two days.
Implications:
- PSD can be misdiagnosed as candidiasis, psoriasis, seborrheic dermatitis, inflammatory bowel disease, or abuse.
- Underdiagnosis delays treatment, increasing the risk of serious secondary complications like acute nephritis and rheumatic fever.
Related Concept Videos
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Streptococcal Pharyngitis
Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

