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Gene therapy for cancer
1Second Department of Surgery, Chiba University School of Medicine, Japan.
Abstract:
The basic strategies for gene therapy that have been explored include immunogene therapy such as cytokine gene transfer, selective prodrug activation, so-called suicide genes, transfer of a tumor suppressor gene, and inhibition of activated oncogenes by antisense mechanisms. Many therapeutic protocols have so far been registered in the office of the Recombinant DNA Advisory Committee, NIH, as of June 1999. Regarding the basic research in gene therapy, we planned a clinical application of gene therapy for an esophageal cancer patient at our institution. We review herein the present status of gene therapy for cancer overseas, and describe a protocol of clinical trials for gene therapy for esophageal cancer at our institution.
Insights
Gene therapy offers various cancer treatment strategies, including immune and suicide gene therapy. This review details current international cancer gene therapy approaches and outlines a clinical trial protocol for esophageal cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gene therapy research has explored diverse strategies for cancer treatment.
- Several gene therapy protocols were registered with the Recombinant DNA Advisory Committee by June 1999.
- International advancements in cancer gene therapy have been significant.
Purpose of the Study:
- To review the current status of gene therapy for cancer internationally.
- To describe a clinical trial protocol for esophageal cancer gene therapy at the institution.
Main Methods:
- Review of existing international gene therapy research and registered protocols.
- Development of a specific clinical trial protocol for esophageal cancer.
Main Results:
- The review covers immunogene therapy, suicide gene therapy, tumor suppressor gene transfer, and antisense inhibition of oncogenes.
- A detailed protocol for clinical trials in esophageal cancer patients is presented.
Conclusions:
- Gene therapy presents multiple promising avenues for cancer treatment.
- The described protocol aims to advance clinical applications of gene therapy for esophageal cancer.