Nonspecific interstitial pneumonia: variable appearance at high-resolution chest CT.

¹Depts of Diagnostic Radiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA. hartman.thomas@mayo.edu

|December 9, 2000

Summary

Computed tomographic (CT) findings in nonspecific interstitial pneumonia (NSIP) show significant variability. This study found a wide range of CT presentations, challenging previous descriptions and aiding differential diagnosis in chronic lung diseases.

Area of Science:

Radiology
Pulmonary Medicine
Pathology

Background:

Nonspecific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia.
Accurate diagnosis of NSIP is crucial for appropriate patient management.
Previous literature suggests characteristic computed tomographic (CT) findings for NSIP.

Purpose of the Study:

To detail the computed tomographic (CT) features observed in patients diagnosed with nonspecific interstitial pneumonia (NSIP).
To contrast these CT findings with those of other chronic infiltrative lung diseases.
To evaluate the consistency of CT findings with prior NSIP descriptions.

Main Methods:

Retrospective review of CT scans from 50 patients with biopsy-proven NSIP.
Consensus review by two experienced thoracic radiologists.
Assessment of CT findings for compatibility with NSIP or alternative chronic infiltrative lung diseases.

Main Results:

Only 22% of patients exhibited CT findings consistent with previous NSIP descriptions.
32% of patients displayed CT findings more suggestive of usual interstitial pneumonia.
46% of patients had nondiagnostic CT findings or findings favoring other lung diseases.

Conclusions:

The computed tomographic (CT) presentation of nonspecific interstitial pneumonia (NSIP) is highly variable.
Observed CT findings in NSIP challenge previously established diagnostic patterns.
A broad spectrum of CT findings necessitates careful interpretation in the diagnosis of NSIP.

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Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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