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IGF-1 and its binding proteins IGFBP-1 and 3 as nutritional markers in prepubertal children
P Martínez de Icaya1, C Fernández, C Vázquez
1Division of Endocrinology and Nutrition, Hospital Severo Ochoa, Leganés, Madrid, Spain.
Insights
Insulin-like growth factor-1 (IGF-1), IGFBP-1, and IGFBP-3 effectively identify nutritional status in children. These biochemical markers correlate with body mass index (BMI) in prepubertal populations.
Area of Science:
- Pediatric Endocrinology
- Nutritional Biochemistry
- Growth Factors
Background:
- Nutritional status assessment in children is crucial for growth and development.
- Biochemical markers offer objective measures of nutritional status.
- Insulin-like growth factor (IGF) system components are implicated in growth and metabolism.
Purpose of the Study:
- To evaluate the utility of IGF-1, IGFBP-1, and IGFBP-3 as biochemical indicators of nutritional status.
- To assess the correlation of these markers with body mass index (BMI) in prepubertal children.
Main Methods:
- Cross-sectional survey design.
- Inclusion of healthy prepubertal children (7-10 years) categorized by BMI (above 90th percentile: overweight; below 10th percentile: underweight).
- Serum levels of IGF-1, IGFBP-1, and IGFBP-3 were measured and compared between groups.
Main Results:
- Overweight children exhibited higher IGF-1 and IGFBP-3 levels and lower IGFBP-1 levels compared to underweight children.
- Significant positive correlations were observed between BMI and IGF-1/IGFBP-3, and a negative correlation with IGFBP-1.
- Albumin and transferrin levels did not differ between the groups.
Conclusions:
- IGF-1, IGFBP-1, and IGFBP-3 are reliable biochemical markers for classifying nutritional status in prepubertal children.
- These markers demonstrate a strong correlation with BMI, indicating their value in assessing caloric nutritional status.
Objective:
To assess the validity of the use of IGF-1, IGFBP-1 and IGFBP-3 as biochemical markers of nutritional status in prepubertal healthy children.
Design:
Cross-sectional survey.
Setting:
Healthy children from the Madrid area.
Participants:
Prepubertal children (aged 7-10 years) with a body mass index (BMI) above the 90th percentile (n = 25) and below the 10th percentile (n = 31) were selected from 2,559 included in the CAENPE study (Food Intake and Nutritional Status in Schoolchildren from Madrid).
Results:
Overweight children were found to have higher serum levels of IGF-1 (306+/-162.2 vs. 209+/-71.2 ng/ml, p<0.001) and IGFBP-3 (3.3+/-1.0 vs. 2.9+/- 0.5 mg/l, p<0.01) and lower serum levels of IGFBP-1 (4.3+/-3.9 vs. 13.8+/-7.4 microg/l, p<0.01). There was a positive correlation with BMI, for IGF-1 and IGFBP-3, and negative correlation for IGFBP-1. No differences in albumin and transferrin concentrations were observed between both groups of children.
Conclusion:
IGF-1, IGFBP-1 and IGFBP-3 clearly classify over- and underweight prepubertal children, showing a good correlation with BMI. They can be used as biochemical markers of caloric nutritional status in this population.