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Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time
R G Lerner1, J Nelson, E Sorcia
1Hematology Section, Department of Medicine, Valhalla, N.Y., USA.
Objectives:
To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).
Methods:
A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to =15 s in patients with acquired coagulation deficits.
Results:
45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to =15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP).
Conclusion:
No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
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