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Rheopheresis: rheologic, functional, and structural aspects.

R Klingel1, C Fassbender, T Fassbender

  • 1Apheresis Research Institute, Cologne, Germany.

Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
|December 9, 2000
PubMed
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Rheopheresis, a specialized plasmapheresis, improves blood flow by removing high molecular weight proteins. This hemotherapy shows promise for treating microcirculation disorders, including age-related macular degeneration.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Ophthalmology

Background:

  • Microcirculation disorders impair tissue oxygenation, leading to acute and chronic symptoms.
  • Impaired microcirculation has rheological, functional, and structural components affecting organs.
  • Rheopheresis is a hemotherapy technique that addresses these dimensions.

Purpose of the Study:

  • To evaluate the therapeutic potential of Rheopheresis.
  • To assess its effects on rheological, functional, and structural aspects of microcirculation.
  • To review clinical data for specific applications, such as age-related macular degeneration.

Main Methods:

  • Rheopheresis utilizes membrane differential filtration (double filtration plasmapheresis).
  • It selectively removes high molecular weight proteins (e.g., fibrinogen, LDL cholesterol, IgM).

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  • This process aims to reduce blood viscosity and erythrocyte aggregation.

    • Main Results:

    • Rheopheresis improves blood flow and microcirculation.
    • It has demonstrated acute rheological and chronic functional/structural effects.
    • Clinical studies confirm its safety and efficacy in conditions like age-related macular degeneration.

    Conclusions:

    • Rheopheresis is an effective extracorporeal hemotherapy for improving microcirculation.
    • It offers a therapeutic approach for conditions linked to impaired microcirculation.
    • Evidence supports its use in age-related macular degeneration treatment.