Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal P2X receptors: localisation and functional properties.

W Nörenberg1, P Illes

  • 1Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, Medizinische Facultät der Universität Leipzig, Germany. noerw@medizin.uni-leipzig.de

Naunyn-Schmiedeberg'S Archives of Pharmacology
|December 9, 2000
PubMed
Summary

Adenosine triphosphate (ATP) acts as a co-transmitter in the nervous system via P2X receptors. Native P2X receptors likely result from various subunit combinations, influencing synaptic signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In memoriam - Francesco di Virgilio: P2X7 receptors in purinergic pathophysiology.

Current opinion in pharmacology·2025
Same author

Astrocytes and major depression: The purinergic avenue.

Neuropharmacology·2022
Same author

Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina.

Cell death & disease·2014
Same author

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

British journal of pharmacology·2014
Same author

Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.

The Journal of pharmacology and experimental therapeutics·2014
Same author

Reply to: 'the discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis'.

Acta physiologica (Oxford, England)·2013

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Extracellular adenosine triphosphate (ATP) functions as a co-transmitter in both central and peripheral nervous systems.
  • ATP mediates its effects through ionotropic (P2X) and metabotropic (P2Y) receptors.
  • P2X receptors are implicated in rapid excitatory synaptic transmission, while P2Y receptor roles remain less understood.

Purpose of the Study:

  • To provide an overview of the distribution of mammalian P2X receptor subunits (P2X1-7) within the nervous system.
  • To compare the pharmacological characteristics of recombinant P2X receptors with native neuronal P2X receptors.
  • To examine the subcellular localization, developmental effects, and interspecies variations of P2X receptors.

Main Methods:

  • Literature review and synthesis of existing data on P2X receptor distribution and function.

Related Experiment Videos

  • Electrophysiological methods to compare recombinant and native neuronal P2X receptor properties.
  • Analysis of studies investigating subcellular distribution, developmental influences, and interspecies differences.

    • Main Results:

    • Seven mammalian P2X receptor subunits (P2X1-7) have been identified.
    • Electrophysiological comparisons reveal similarities and differences between recombinant and native P2X receptors.
    • P2X receptors exhibit variations in subcellular distribution, development, and across species.

    Conclusions:

    • The diverse properties of native neuronal P2X receptors are best explained by the heteromeric assembly of different P2X receptor subunits.
    • Understanding P2X receptor subunit composition is crucial for elucidating their role in synaptic transmission.