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Published on: December 30, 2016
Crystal structure of the F component of the Panton-Valentine leucocidin
J D Pédelacq1, G Prévost, H Monteil
1Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS, Toulouse, France.
Abstract:
Leucocidins and gamma-hemolysins are bi-component staphylococcal toxins that form lytic transmembrane pores. Their cytotoxic activities involve the synergistic association of a class S and a class F component, produced as water-soluble monomers which assemble on the surface of specific cells. The structure of the F protein from Panton-Valentine leucocidin, solved at 2.0 A resolution, and sequence alignment suggest that it represents the fold of any secreted protein in this family of toxins. The comparison of this structure to that of the homoheptameric alpha-hemolysin provides some insights into the molecular events that may occur during pore formation.
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