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Related Experiment Videos

Reduced nasal nitric oxide in diffuse panbronchiolitis.

H Nakano1, H Ide, M Imada

  • 1Department of Internal Medicine, School of Nursing, Asahikawa Medical College, Asahikawa, Hokkaido, Japan. kin@asahikawa-med.ac.jp

American Journal of Respiratory and Critical Care Medicine
|December 9, 2000
PubMed
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Diffuse panbronchiolitis (DPB) is a lung disease causing chronic infections. Patients with DPB have significantly lower nasal nitric oxide (NO) levels, suggesting NO may play a role in the disease and aid diagnosis.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Medical Diagnostics

Background:

  • Diffuse panbronchiolitis (DPB) is a chronic inflammatory airway disease characterized by respiratory bronchiolitis, bronchiectasis, and sinusitis.
  • Patients with DPB experience recurrent airway infections due to impaired mucociliary function.
  • Low nasal nitric oxide (NO) is typically associated with primary ciliary dyskinesia syndrome and cystic fibrosis.

Purpose of the Study:

  • To investigate whether patients with DPB exhibit abnormal nasal nitric oxide (NO) levels.
  • To determine if nasal NO measurement can serve as a diagnostic marker for DPB.

Main Methods:

  • Nasal NO levels were measured using the chemiluminescence technique in 15 healthy subjects and 8 patients diagnosed with DPB.
  • Air samples were collected directly from the nasal passages of all participants.

Related Experiment Videos

  • The effect of erythromycin treatment on nasal NO was assessed in four control subjects.

    • Main Results:

    • Nasal NO levels in DPB patients were significantly lower (88%) compared to age-matched healthy controls (69 +/- 70 nl/min vs. 556 +/- 87 nl/min, p < 0.001).
    • A 2-week course of erythromycin treatment did not alter nasal NO levels in the control subjects studied.
    • This study identifies DPB as the third pulmonary disease associated with reduced nasal NO.

    Conclusions:

    • Reduced nasal NO is a characteristic finding in patients with diffuse panbronchiolitis (DPB).
    • Low nasal NO levels may be implicated in the pathogenesis of DPB.
    • Nasal NO measurement presents a potential noninvasive diagnostic tool for identifying DPB.