[Glycide metabolism disorder in renal failure, therapeutic sequelae]

The in vitro effects of increased concentration of urea, creatinine, phosphate, glucose and of decreased concentration of potassium and calcium on the inhibitory effects of IGU was studied. The following results were obtained: 1. Urea, creatinine and increased concentration of phosphate in the degrees significant clinically did not influence the effect of IGU. 2. Decreased concentration of potassium did not influence utilization of glucose, but abolished completely the inhibitory effect of IGU. 3. Increased concentration of glucose increased its utilization, but did not abolish the inhibitory effect of IGU. The therapeutic implications of these findings for glycid metabolism in renal insufficiency are analysed.